转化生长因子βⅠ型受体在老年胃癌组织的表达及其临床意义

TGF-βRⅠ Expression and its Clinical Significance in the Elderly Gastric Carcinoma

摘要: 目的　研究TGF βRⅠ表达与老年胃癌的生物学行为和预后的关系。方法　应用免疫组化S P方法检测 5 0例内窥镜胃良性活检标本及 6 1例老年胃癌手术标本中TGF βRⅠ的表达情况。结果　胃良性活检标本TGF βRI表达阳性率 >95 .0 0 %, 胃癌表达阳性率为 31.5 %, 其表达水平与胃癌浸润胃壁深度和 pTNM分期呈负相关 (P <0 .0 1)。TGF βRⅠ阳性者术后 3、5年生存率优于阴性者。结论　检测胃活检粘膜及老年胃癌组织中TGF βRⅠ表达状况, 有助于了解胃粘膜癌变倾向及老年胃癌生物学行为和对患者预后的判断。

Abstract: Objective To study the relations between TGF-βRIexpression and carcinogenesis of gastric mucosa, biological behavior or prognosis in gastric carcinoma. Methods The expression of TGF-βRI was examined immunohistochemically in benign gastric mucoas, resected gastric carcinoma, using anti-polyclonal antibody. Results Benign gastric mucosa tested, 95% showed positive staining of TGF-βRI and 31.15% did in 61 old gastric cancer patients. Expression of TGF-βRI is inversely correlated with tumor invasion and the...