生化调节方案MTX/5-FU/DDP(MFP)治疗晚期胃癌的临床观察

Study on The Effects of Biochemical Modulation Regimen MTX/ 5-FU/DDP (MFP) in the Treatment of Advanced Gastric Cancer

摘要: 目的　探讨生化调节方案MTX/5 FU/DDP(MFP)治疗晚期胃癌的疗效与毒性。方法　 1998年 6月至 2 0 0 0年 6月应MTX/5 FU/DDP(MFP)治疗晚期胃癌 4 2例。结果　全组总有效率 (CR +PR) 47.6 %, 对初次化疗患者有效率 6 6 .7%, 对曾接受过化疗者有效率 37.0 4 %, 对曾接受过 5 FU治疗者有效率 36 .8%。统计学分析显示MFP方案对初次化疗者的有效率显著高于以往接受过化疗者。无明显不良反应。结论　该方案对晚期胃癌疗效较好, 不良反应轻, 而且十分经济便宜, 值得临床推广应用。

Abstract: Objective To study the effect and toxicity of biochemical modulation regimen MTX/5-FU/DDP(MFP)in the treatment of advanced gastric cancer. Methods From June 1998 to June 2000,42 patients were treated with TMX/5-FU/DDP(MFP) regimen. Results The total response rate was (CR+PR)47.6% for 42 patients. The response rate for chemotherapy-naive patients and patients who had received chemotherapy were 66.7%, 37.04% respectively ( P <0.05). For patients who had received 5-FU-based combination chemotherapy t...