PTEN和survivin在乳腺癌中的表达及其临床意义
The Clinical Significance and Expression of PTEN, survivin in Breast Cancer
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摘要: 目的研究PTEN和survivin在乳腺癌组织中的表达及其与乳腺癌细胞增殖活性的相关性,并探讨其与临床病理的关系。方法用免疫组化方法(SP法)对60例乳腺癌和36例乳腺增生症的石蜡包埋标本进行PTEN、survivin、PCNA检测,其中PCNA指数作为衡量乳腺癌细胞增殖活性的参数。结合病人的临床病理资料进行χ2检验和t检验。结果PTEN在乳腺癌中的高表达率明显低于乳腺小叶增生(P<0.05);PTEN的表达与乳腺癌细胞增殖活性显著相关(P<0.05);PTEN的表达水平与腋淋巴结转移和远处转移呈负相关(P<0.05),与ER水平和5年生存率呈正相关(P<0.05)。survivin在乳腺癌中的阳性表达率明显高于乳腺增生症(P<0.05);survivin的表达与乳腺癌细胞增殖活性呈正相关(P<0.05)。PTEN和survivin在乳腺癌中的表达呈负相关(P<0.05)。结论PTEN和survivin的表达与乳腺癌细胞增殖活性显著相关;PTEN可以作为一个判断乳腺癌预后的指标;PTEN和survivin可能共同参与了乳腺癌的发生和发展。Abstract: Objective To study the expression of PTEN, survivin and their clinical significance. Methods The expression of PTEN, survivin, PCNA was evaluated in 60 cases paraffin embedded of breast cancer and 36 cases of mammary gland hyperplasia by immunohistochemical technique(SP), labeling index (PI) of PCNA was acted as a marker of the cellular proliferating activity. Clinicopathologic elements were analyzed by chi square test(χ2 ) and t-test. Results The expression rate of PTEN was lower in breast cancer patient...
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