β-Catenin,cyclinD1及c-myc在肝细胞癌中的表达

Expression of Beta-catenin,cyclinD1 and C-myc Genes in Hepatocellular Carcinoma

摘要: 目的探讨β-Catenin、cyclinD1及c-myc蛋白的表达与肝癌临床病理参数的关系。方法采用EnVisionTMplus免疫组织化学方法研究β-Catenin、cyclinD1及c-myc蛋白在52例HCC及癌旁肝组织中的表达情况。结果52例HCC中β-Catenin、cyclinD1及c-myc蛋白染色阳性率分别为55.8%、48.1%及53.8%,癌旁肝组织的阳性率为36.5%、25.0%及32.7%,β-Catenin、cyclinD1及c-myc在HCC及癌旁肝组织两者间有显着性差异(P<0.05)。在HCC中β-Catenin的阳性表达与cyclinD1、c-myc的阳性表达密切相关(P=0.0108,r=0.3920;P=0.0295,r=0.3406)且呈正相关;β-Catenin、cyclinD1及c-myc在人肝癌组织中的检出率与肝外转移、术后复发及肿瘤分化程度明显有关(P<0.05),cyclinD1的检出率与门静脉癌栓也明显有关(P<0.05),β-Catenin的检出率与临床分期和门静脉癌栓也有显著性差异(P<0.05)。结论β-Catenin、cyclinD1及c-myc蛋白...

Abstract: Objective To investigate the correlation between the clinic pathologic parameters of hepatocellular carcinoma(HCC) and the expression of beta-catenin、cyclinD1 and c-myc genes. Methods Immunohistochemical technique(EnVision~ TM plus) was applied to detect the expression of beta-catenin、cyclinD1 and c-myc proteins in 52 HCC tissues and surrounding tissues. Results The rates of positive immunostaining of beta-catenin、cyclinD1 and c-myc in the HCC tissues were 55.8% 、 48.1% and 53.8% . The rates of positive in t...