奥铂治疗恶性心包积液的临床疗效观察

Therapeutic Effect of Oxaliplatin in the Treatment of Malignant Hydropericardium

摘要: 目的观察奥铂治疗恶性心包积液的临床疗效。方法本组29例,支气管肺癌21例(NSCLC19例,SCLC2例),乳腺癌4例,食管-胃癌4例。随机分组:奥铂治疗组15例,对照组(顺铂)14例。超声引导下心包置管引流,心包腔注入奥铂(治疗组)50~100mg/次或顺铂(对照组)30~50mg/次,5%GS或NS稀释至20~40ml,间歇性给药2~3次。结果奥铂治疗组和对照组的完全缓解率及有效率分别为26.7%、21.4%和73.3%、64.3%(P>0.05)。奥铂治疗组与对照组的疗效差异无显著性,毒副作用轻微,无心脏骤停,心肌、冠状血管损伤等严重并发症。结论奥铂治疗恶性心包积液疗效显著,毒副作用轻。

Abstract: Objective To study the effect of Oxaliplatin (L-OHP) in the treatment of Malignant Hydropericardium. Methods 29 patients with malignant hydropericardium were lung cancer 21 cases(NSCLC 19 cases, SCLC 2 cases),breast cancer 14 cases and esophagogastric cancer 4 cases, were divided into 2 groups by random. One group of 15 patients with L-OHP and the other of 14 patients was treated with DDP. L-OHP (50～100mg) or DDP(30～50mg), diluted to 20～40ml with 5%GS or NS, were injected into pericardium and may given tow ...