50 例原发性肝癌血清多肿瘤标志物的联合检测研究

Combined Different Tumor Markers in Detecting 50 Primary Hepatic Carcinoma Cases

摘要: 目的观察原发性肝癌（PHC）患者血清多肿瘤标志物联合检测的阳性检出率。方法应用多肿瘤标志物蛋白质芯片诊断系统，观察50例PHC、13例其他恶性肿瘤患者、43例炎症性疾病患者以及220例正常对照的血清AFP、CA19—9、CA125、CEA、CA242的阳性表达率。结果 PHC组AFP、CA19—9、CA125、CEA、CA242的阳性检出率分别为86％、42％、38％、24％、18％，该5项肿瘤标志物联合检测，阳性栓出率可达96．00％。结论联合检测AFP、CA19—9、CA125、CEA、CA242等肿瘤标志物，有利于提高PHC的诊断率。

Abstract: Objective 　To increase the detection rate of primary hepatic carcinoma (PHC) by applying different tumor markers. Methods 　Using the different tumor markers Protein Chip Diagnose System to determine and analyze the concent ration values of 5 tumor markers in the sera of 50 PHC patient s, 13 malignant tumor patient s, 43 inflammation patient s and 230 normal persons. Results 　The positive detection rate of AFP, CA19-9, CA125, CEA and CA242 of PHC was 86 %, 42 %, 38 %, 24 %, 18 % respectively. The total positive detection rate of PHC with combined five tumor markers reached to 96. 00 %. Conclusion 　The positive diagnostic accuracy of PHC can be improved by combined the five tumor markers.