细胞外信号调节蛋白激酶在膀胱癌中表达的意义

The expression significance of extracellular signal-regulated kinase in bladder cancer

摘要: 目的　探讨细胞外信号调节蛋白激酶 (ERK ) 1在膀胱癌发病机制中的作用及其临床意义。方法　应用免疫组化方法和DNA图像分析技术检测膀胱癌组织中ERK1成纤维细胞生长因子受体 (FGFR)及c met的表达和DNA倍体及含量。结果　膀胱癌中ERK1阳性率为 88.9%, 显著高于正常膀胱组织的6 6 .7%, 而且与肿瘤病理分级、复发及DNA多倍体、DNA含量和FGFR表达密切相关, 但与肿瘤分期和c met表达之间相关无显著性意义。结论　ERK1表达异常在膀胱癌发病过程中起重要作用, 在一定程度上可以反映肿瘤生物学特征。

Abstract: Objective To investigate the role of extracellular signal regulated kinase (ERK) 1 in pathogenesis of bladder cancer and its relationships with tumor biological behaviors and fibroblast growth factor receptor (FGFR) and c met. Methods ERK1,FGFR and c met expressions were determined by immunohistochemistry technique in 88 cases with bladder cancer and 9 cases with normal bladder tissues. DNA parameters in patients with bladder cancer were determined by DNA image cytometry. Results The positive expres...