64例鼻腔及副鼻窦内翻性乳头状瘤及癌变的临床病理分析

Clinico pathologic analysis of 64 cases of the inverted papilloma and malignant changes in nose and paranasal sinus

摘要: 目的　探讨 6 4例鼻腔和副鼻窦内翻性乳头状瘤的临床、病理诊断的特点以及与预后的关系。方法　采用AB及网状纤维染色法观察该瘤粘液细胞和基底膜, 计算瘤细胞核分裂相数, 收集有关临床病理资料, 并随访。结果　 (1)此瘤好发于成年男性, 病程较长 ;临床常以鼻塞流脓涕及鼻衄为主要症状。 (2 )瘤组织呈乳头状或实巢状向粘膜间质内生长为其组织学特征。 (3)瘤细胞不典型增生Ⅱ级、Ⅲ级及核分裂相 >5个 10HF患者易复发。 (4)瘤细胞不典型增生Ⅲ级核分裂 10～ 2 5 10HF患者易癌变。结论　根据临床和组织学特征提出瘤细胞不典型增生, 核分裂相数目多少是预测肿瘤复发和恶变的重要指标, 复发是导致恶变的重要指标之一。

Abstract: Objective To study the features of the inverted papilloma of nose and paranasal sinus in clinic and pathological diagnosis, and relationship in prognosis. Methods 64 cases of this tumor were analyzed. Data in clinicopathologic were collected. Myxocyte and basal membrane were observed with AB(Alcian blue) staining,reticullar fiberstaining and mitotic index were counted by light.All patients were followed up. Results The tumor occurred in male, has a long course of disease. The main symptom was prsented as ...