紫杉醇为主方案治疗中晚期上消化道癌的临床研究

Paclitaxel combination with other chemotherapeutic agents for advanced upper digest tract carcinoma patients

摘要: 目的　观察紫杉醇为主方案对中晚期上消化道癌复治患者的疗效和不良反应。方法　全组 32例患者, 其中食管癌 8例, 贲门癌 10例, 胃癌 14例, 应用TP(紫杉醇 6 0mg m2, d1、d8、d15, 顺铂 2 0mg d, d1～ 5 )或TF方案 (紫杉醇 6 0mg m2, d1、d8、d15, 氟脲嘧啶 2 5 0mg (m2 .d), d1～ 14 )治疗, 2 8天为一周期, 平均用药3.0 6个周期。结果　总缓解率为 4 0 .6 %, 其中完全缓解 5例, 部分缓解 8例, 无变化 15例, 进展 4例。食管癌缓解率 37.5 %, 贲门癌缓解率 30 .0 %, 胃癌缓解率 5 0 .0 % ;中位缓解期 4 .5个月。主要的不良反应为骨髓抑制和粘膜炎。结论　紫杉醇为主方案对复治性上消化道癌患者疗效较好, 不良反应可以耐受, 值得深入研究。

Abstract: Objective To evaluate the effect and toxicity of paclitaxel combination with other chemotherapeutic agents for advanced upper digest tract carcinoma patients. Methods Thirty two patients, which were 8 esophageal cancer patients, 10 cardiac cancer patients and 14 gastric cancer patients, were treated with TP or TF regimen, Cycles repeated for 28 days. All the patients received over two cycles of chemotherapy, median 3.06 cycles. Results The overall response rate was 40.6%(CR 5, PR 8, NC 15,PD 4), w...