GPDA 、CA72-4 、CA50 联检在胃癌诊断中的价值

doi:10.3971/j.issn.1000-8578.3110

GPDA 、CA72-4 、CA50 联检在胃癌诊断中的价值

The Value of Combined Detection of GPDA, CA7-24 and CA50 in Diagnosis of Gastric Cancer

摘要

摘要: 目的探讨GPDA、CA72-4、CA50三项联检对胃癌的临床诊断价值。方法采用电化学发光免疫分析、放射免疫法及全自动生化分析仪等技术，对125例胃癌、77例胃良性疾病、50例正常健康人血清进行GPDA、CA72-4、CAS0三项检测。结果胃癌组GPDA、CA72-4、CA50敏感性分别为62．4％、68．0％，54．4％；特异性分别为97．6％、97．6％、98．4％。三项联检敏感性提高到89．6％，与单检比较有统计学意义（P〈0．05）；同时特异性并未明显降低，仍有93．7％。结论 GPDA、CA72-4、CA50可作为临床诊断胃癌的肿瘤标志物，三项联检可明显提高阳性检出率。

Abstract: Objective 　To study the diagnostic value of Glycyl Proline Dipeptidyl Aminopeptidase ( GPDA), CA7-24 and CA50 in gastric cancer. Methods 　Serum levels of GPDA, CA7-24 and CA50 in 125 patients with gastric cancer, 77 patients with benign gastric tumor and 50 normal controls were measured by electro-chemiluminescence immuno-assay (ECLIA) and radioimmunoassay and automatic biochemical analyzer. Results 　Sensitivities of GPDA, CA7-24 and CA50 in gastric cancer group were 62. 4 %, 68. 0 % and 54. 4 %, respectively, and the specificities were 97. 6 %, 97. 6 % and 98. 4 %, respectively. The sensitivity of combined detection of three tumor markers increased to 89. 6 %, and the specificity was 93. 7 %. Conclusion 　GPDA, CA7-24 and CA50 can serve as the serum tumor marker in clinical diagnosis of gastric cancer. Combined detection of three kinds of serum tumor makers increases the detective positive rate.

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