直肠癌中p53基因与血管内皮生长因子表达的关系

The relationship of the expression of p53 and vascular endothelial growth factor in rectal carcinoma

摘要: 目的　研究直肠癌中血管内皮生长因子 (VEGF)的表达与 p5 3基因之间的关系。方法　采用免疫组化方法对 4 5例直肠癌标本中VEGF和 p5 3基因的表达进行检测。结果　在直肠癌中VEGF的表达率为 6 6 .6 7% (30 / 45 ), p5 3的表达率为 5 1.11% (2 3/ 45 ) ;在VEGF表达较高的区域, p5 3的表达亦较强, 二者之间具有相关性 (P <0 .0 5 ), 且与直肠癌的淋巴结转移相关 (P <0 .0 5 )。结论　在直肠癌中, VEGF的表达与 p5 3基因的表达呈正相关, 在直肠癌的转移中起重要作用

Abstract: Objective To investigate the relationship of the expression of p53 and vascular endothelial growth factor (VEGF) in rectal carcinoma . Methods The expression of p53 and VEGF was detected by using immunohistochemical method in 45 Cases of rectal cancer tissue . Results The expression rate of VEGF and p53 was 66.67%(30/45),51.11%(23/45) respectively ; In the areas with higher VEGF expression there was more intensive p53 expression, χ 2 test showed that VEGF expression was correlated with p53 ( P <0...