血管内皮生长因子在人脑胶质瘤侵袭中的作用
Expression of vascular endothelial growth factor in human glioma
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摘要: 目的 研究血管内皮生长因子 (Vascularendothelialgrowthfactor, VEGF)在脑胶质细胞瘤中的表达情况, 探讨其表达与肿瘤的恶性程度、肿瘤侵袭及预后的关系。方法 采用免疫组织化学染色检测 5 2例脑胶质瘤标本, 4例垂体腺瘤, 5例正常脑组织的VEGF表达水平。结果 在正常脑组织中未见VEGF免疫组化染色阳性细胞, 垂体腺瘤偶有表达, 脑胶质瘤组织中均有VEGF表达 (P <0 .0 5 )。随着脑胶质瘤恶性程度的增加, VEGF的表达增高 (P <0 .0 1)。生存期 <3年者VEGF的表达显著高于生存期 >3年者 (P <0 .0 1)。结论 VEGF的表达与胶质瘤的恶性程度和侵袭性等有关, 并对其预后有一定的意义Abstract: Objective To study the exprssion of vascular endothelial growth factor in human glioma, and explore the relationship between VEGF and neoplasm invasion?malignant degree and prognosis. Methods A Immunohistochemical method was used to detect the level of VEGF in 52 cases of glioma,4 cases of pituitary adenoma,5 cases of normal brain tissue. Their relation to clinic data was also comparatively analyzed. Results All gliomas expressed VEGF protein,but no VEGF positive staining cell was found in normal brian ti...
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