肝癌的糖代谢、胰岛素和C肽变化的研究

doi:10.3971/j.issn.1000-8578.2817

肝癌的糖代谢、胰岛素和C肽变化的研究

Changes of Glucose Metabolism,Insulin and C-peptide in L iver Cancer

摘要

摘要: 目的　探讨肝癌糖代谢异常的特点，外周血胰岛素(INS)、C肽(C-P)水平的变化及胰岛β细胞的功能状态。方法　对21例原发性肝癌和20例正常人进行葡萄糖耐量(OGTT)、胰岛素释放和C肽释放试验，分别比较空腹及服糖后2小时的血糖(BG)、INS和C-P水平。结果　肝癌组2 小时的BG、INS和C-P水平较对照组同期显著增加(P＜0.05)，肝癌组2小时/空腹INS 比值、2小时/空腹C-P比值显著高于对照组(P＜0.05)。结论　肝癌患者糖代谢异常表现为糖耐量减低，餐后高胰岛素血症和高C肽血症可能是由于β细胞代偿性分泌增多。

Abstract: Objective To investigate the characteristics of abonrmal glucose metabolism in Liver cancer,the changes of insulin(INS) and C-peptide (C -P) levels in peripheral blood,and the function of islet β-cell. Methods Tests of glucose tolerance,INS and C-P release were performed in 21 prim ary liver cancer patients and 20 normal control persons.The blood glucose(BG)、I NS and C-P levels at fasting and 2h after dinner were compared respectively. Results The levels of BG、INS and C-P at 2h after dinner were signific antly higher in liver cancer group than those in control (P＜0.05)，the ra tios of INS and C-P at 2h versus those before dinner were also significantly hi gher (P＜0.05). Conclusion Main features of abnormal glucose me tabolism in Liver cancer were impaired glucose toleranle,hyper-insulinemia and hyper-c-peptidemia affter dinner might be due to compensatory hypersecretion o f islet β-cell.

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