HELF联合化疗治疗晚期胃癌临床研究

doi:10.3971/j.issn.1000-8578.2807

HELF联合化疗治疗晚期胃癌临床研究[J]. 肿瘤防治研究, 2000, 27(03): 220-221. DOI: 10.3971/j.issn.1000-8578.2807

引用本文:

HELF联合化疗治疗晚期胃癌临床研究[J]. 肿瘤防治研究, 2000, 27(03): 220-221. DOI: 10.3971/j.issn.1000-8578.2807

Clinical Study of HELF Combined Chemotherapy for Patients With Advanced Gastric Carcinoma[J]. Cancer Research on Prevention and Treatment, 2000, 27(03): 220-221. DOI: 10.3971/j.issn.1000-8578.2807

Citation:

Clinical Study of HELF Combined Chemotherapy for Patients With Advanced Gastric Carcinoma[J]. Cancer Research on Prevention and Treatment, 2000, 27(03): 220-221. DOI: 10.3971/j.issn.1000-8578.2807

HELF联合化疗治疗晚期胃癌临床研究

Clinical Study of HELF Combined Chemotherapy for Patients With Advanced Gastric Carcinoma

摘要

摘要: 目的观察羟基喜树硷(HCPT),足乙叉甙(VP-16),甲酰四氢叶酸钙(LV)加5一氟脲嘧啶(5-Fu)组成HELF联合化疗方案对晚期胃癌的疗效.方法自1993年4月至1997年2月,用HELF方案治疗52例晚期胃癌,具体用药:HCPT8mg/m2/d iv d1～5;VP-16 60 mg/m2/d iv d1～5;LV100 mg/m2/div d1～5;5-FU600 mg-/m2/d iv d1～5.结果 52例病人中达完全缓解的有4例(CR7.69%);部分缓解25例(PR48.07%);总有效率(CR+PR)是55.76%,其有效率高于对照组ELF方案41.16%(P＜0.05).中位生存期10个月也优于对照组7.5个月(P＜0.05).毒副反应轻.

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