高聚金葡素与顺铂治疗恶性胸腔积液的疗效观察

doi:10.3971/j.issn.1000-8578.2804

高聚金葡素与顺铂治疗恶性胸腔积液的疗效观察

Clinical Efficacy of Highly Agglutinative Staphylococci plus Cisplatin in the Treatment of Malignant Pleural Effusions

摘要

摘要: 目的　观察高聚金葡素对晚期肺癌合并恶性胸腔积液的疗效。方法　32例设为对照组，常规全身行EP方案化疗并顺铂胸腔内注射；观察组32例，在作上述常规治疗的同时，加用肌注和胸腔内注入高聚金葡素。结果　观察组胸水吸收的有效率达71.9%，karnofsky评分上升率为78.1%均优于对照组的43.8%和40 .6%(P<0.01)，而白细胞减少和胃肠道反应的发生率均比对照组低(P<0.01)。结论　在全身和胸腔内应用抗癌药治疗晚期肺癌合并恶性胸腔积液的基础上加用高聚金葡素可提高胸水吸收的有效率，改善生活质量，减少化疗毒副作用。

Abstract: Objective To evaluate the effect of therapy of highly agg lutinative staphylococci (HASL) plus cisplatin (DDP) in the treatment of maligna nt pleural effusion in the advanced lung cancer. Methods 64 cases wit h malignant effusions were randomly classified into two groups.32 cases in the H ASL group were treated with HASL plus DDP intrapleural injection.32 cases in the control group were with DDP intrapleural injection. Results Clinical effective rate of the reduction of the volume of pleural effusions in HASL grou p was 71.9%，which significantly higher than the effective rate (43.8%) in con trol group (P<0.01). Conclusion Combination therapy of HASL plus DDP can effectively control the pleural effusion in advanced lung cancer,improv e the life quality of the patients and lower the toxicity of side effects in che motherapy.

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