Abstract: Objective 　To explore the expression of p57^kip2、Cyclin E in human gliomas and its clinical significances. Methods 　The expression of p57^kip2and Cyclin E proteins in human glioma tissues in 46 patients was detected by SP immunohistochemical technique. Results 　The p57^kip2 protein positive-expression rate in human glioma was 34. 8 %, which was lower than that in normal brain tissue ( P < 0. 05) . The p57^kip2 protein positive-expression correlated significantly with clinicopathologic grade ( P < 0. 05) and the two-year survival time ( P > 0. 01) . The Cyclin E positive-expression rate in human glioma was 58. 6 %. The Cyclin E positive-expression also correlated significantly with clinicopathologic grade ( P <0. 05) and the two-year survival time ( P < 0. 05) . There were significant correlation with the expression of p57>>kip2 protein and Cyclin E protein ( rs = - 0. 359, P < 0. 05) . Conclusion 　The expression of p57>>kip2 protein and Cyclin E protein plays an important role in the development of glioma . They also correlated significantly with the differentiation degree of human gliomas and Prognosis.