卡莫氟联合后程加速超分割放疗治疗食管癌的临床研究

Clinical Study of Carmofur Combined with Late Course Accelerated Radiation in Esophagus Carcinoma

摘要: 目的　研究卡莫氟联合后程加速超分割放疗治疗食管癌的疗效。方法　自 1997年 1月～ 1997年 7月对 2 10例食管癌病人随机分为常规分割组 (常规组 )、后程加速超分割组 (后超组 )和卡莫氟联合后程加速超分割组 (联合组 )各 70例, 常规组每次 2Gy, 后加组和联合组先采取常规照射, 30Gy后改为每次 1.5Gy, 2次 /天, 两次之间间隔 6小时, 3组放疗总量均为 (6 0～ 6 6 )Gy。联合组给予卡莫氟 2 0 0毫克 /次, 每日口服 3次。结果　常规组、后加组、联合组 5年局部控制率分别为 2 4 .3%、5 7.1%和 6 4 .3%, 联合组高于常规组和后加组 (P <0 .0 5 ), 5年生存率分别为 8.6 %、2 4 .3%和 4 1.4 %, 联合组高于后加组和常规组 (P <0 .0 5 )。结论　联合组较常规组和后加组治疗食管癌的效果明显提高

Abstract: Objective To study the effect of carmofur combined with late course accelerated radiation for esophagus carcinoma. Methods 210 patients with esophagus squamous cell carcinoma were treated from Jan. 1997 to July 1997. They were divided into three groups:conventional fraction(CFR) group,late course accelerated radiation(LCAR)group and Carmofur combined with late course accelerated radiation (CLCAR) group.CLCAR and LCAR group received (2.0)Gy per fraction,five fractions a week before 30Gy,then followed by acc...