吸烟、饮酒与胆道癌关系的全人群病例对照研究

Cigarette Smoking,Alcohol Consumption and Risk of Biliary Tract Cancers:A Population-based Case-control Study in Shanghai,China

摘要: 目的　探讨吸烟、饮酒与胆道癌的关系。方法　采用全人群病例对照研究, 研究对象为 1997年6月 1日～ 2 0 0 1年 5月 31日期间确诊的、年龄在 35～ 74岁的上海市区 6 2 7例胆道癌新发病例以及按性别、年龄 (5岁一组 )频数配对的 95 9例人群对照。采用非条件logistic回归模型分析吸烟、饮酒与胆道癌的关系。结果　男性中, 吸烟对肝外胆管癌和壶腹癌各组的调整OR均大于 1,现仍吸烟者的调整OR分别为 1.5 1(95 %CI:0 .86～ 2 .6 6 ), 1.5 8(95 %CI:0 .6 9～ 3.5 8) ;OR随吸烟年限增加和开始吸烟年龄提早有所升高, 但均未达显著水平。饮酒对胆道癌各组OR均无统计学意义。结论　吸烟也许与肝外胆管癌、壶腹癌有联系, 未发现吸烟与胆囊癌的显著性关联 ;未发现饮酒与胆道癌的显著性关联。

Abstract: Objective To investigate the relationship between cigarette smoking, alcohol consumption and biliary tract cancers. Methods A population-based case-control study was conducted in urban Shanghai from 1 June 1997 to 31 May 2001 involving interviews with 627 newcases of biliary tract cancers aged 35 to 74 years and 959 population controls frequency-matched to cases by gender and age in five-years group. All subjects were interviewed in person by trained interviewers by use of a structured questionnaire. Uncon...