人脑胶质瘤中VEGF 和整合素ανβ3 的表达及相关性研究

doi:10.3971/j.issn.1000-8578.2484

人脑胶质瘤中VEGF 和整合素ανβ3 的表达及相关性研究

Study on Expression and Relationship between Vascular Endothelial Growth Factor and Intergrin ανβ3 in Human Gliomas

摘要

摘要: 目的研究血管内皮生长因子(VEGF)和整合素ανβ3(INT ανβ3)在不同病理级别人脑胶质瘤中的表达．并探讨两者之间的关系。方法采用免疫组化SABC法和图像分析技术检测65倒不同病理级别人脑胶质瘤标本中VEGF和INT ανβ3的表达水平。结果 VEGF在不同级别胶质瘤中表达的平均光密度值(ALD)分别为0．05177±0．019683,0．07399±0．02798和0．09168±0．03671,INT ανβ3在不同级别胶质瘤中表达的平均光密度值(ALD)分别为0．04872±0．01869，0．06065±0．02998和0．08189±0．03953，差异均有显著性意义(P<0．05)．二者的表达水平呈正相关(r=0．835，P<0．01)。结论 VEGF和INT ανβ3在人脑胶质瘤中的表达水平与胶质瘤的恶性程度密切相关，两者之间呈正相关．提示二者在人脑胶质瘤的恶性生物学行为中起重要作用。

Abstract: Objective 　To study the expression of vascular endothelial growth factor (VEGF) and integrin ανβ3 ( INTανβ3) in different pathological grade human gliomas, and the relationship between them. Methods 　The expression of VEGF and INTανβ3 in 65 cases human gliomas were detected with SABC immunohistochemical technique and image analysis system. Results 　The average light density of VEGF and INTανβ3 in different grade gliomas were 0. 05177 ±0. 019683, 0. 07399 ±0. 02798, 0. 09168 ±0. 03671 and 0. 04872 ±0. 01869, 0. 06065 ±0. 02998, 0. 08189 ±0. 03953, respectively. The difference of VEGF and INTανβ3 in different grade gliomas were significant ( P < 0. 05) . The expression of VEGF was correlated with the expression of INTανβ3 ( r = 0. 835, P < 0. 01) . Conclusion 　The expression of VEGF and INTανβ3 in different pathological grade human gliomas were associated with malignant degree of human gliomas and the expression of VEGF correlated with the expression of INTανβ3, which suggest both of them play import role in malignant biological behaviors of human gliomas.

HTML全文

参考文献(0)

施引文献

资源附件(0)