环氧合酶-2 在子宫内膜癌中的表达及其与肿瘤血管形成的关系

doi:10.3971/j.issn.1000-8578.2473

环氧合酶-2 在子宫内膜癌中的表达及其与肿瘤血管形成的关系

Cyclooxygenase-2 Expression in Endometrial Carcinoma and Their Relationship with Angiogenesis

摘要

摘要: 目的探讨环氧合酶-2(Cyclooxygenase-2，COX2)在子宫内膜癌组织中表达及与肿瘤血管形成的关系。方法采用免疫组化SIP方法检测34例子宫内膜癌组织COX-2和血管内皮生长因子(Vascu1arendothelial growth factor，VEGF)的表达和微血管密度(Microvessel density，MVD)，观察COX-2表达与肿瘤血管形成之间的相关性。结果 COX-2在子宫内膜癌组织中的阳性表达率为64．7％，而对照组正常子宫内膜均未见表达，内膜癌组的中分化细胞COX-2蛋白的表达高于低分化细胞，差异有显著性(P<0．05)；COX-2表达阳性组和阴性组MVD分别为(41．53±19．10和28．79±8．20)，两组比较具有显著性差异(P<0．05)。COX-2的表达评分与VEGF及MVD高度均呈正相关(P<0．01；P<0．0001)。结论 COX-2可能主要参与子宫内膜癌发生的早期；子宫内膜癌组织中COX-2的高表达可能在VEGF诱导肿瘤血管形成的过程中起重要作用。

Abstract: Objective 　To investigate the expression of cyclooxygenase-2 (COX-2) in endome-trial carcinoma and its relationship to angiogenesis. Methods 　The expression of COX-2 and vascular endothelial growth factor (VEGF) in 34 cases of endometrial carcinoma was evaluated by immunohistochemistry SP staining. Microvessel density (MVD) of endomet rial carcinoma was also determined with anti-CD34 as the label. Results 　The expression late of COX-2 in 34 cases was 64. 7 % but not in cont rol endomet rium. The level of COX-2 expression was higher in grade Ⅱtumor than in grade Ⅲ tumor ( P < 0. 05) . MVD was (41. 53 ±19. 10) and (28. 79 ±8. 20) in endomet rium carcinoma positive and negative for COX-2 ( P< 0. 05) . The expression of COX-2 was positively correlated with expression of VEGF and MVD ( P <0. 01 ; P < 0. 0001, respectively ) . Conclusion 　COX-2 may involve early in endomet rium neoplastic progression. The expression of COX-2 in endomet rial carcinoma may induce the expression of VEGF, increase angiogenesis and enhance tumor growth and invasion.

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