肺鳞癌中p53 与PCNA 的表达及临床意义

doi:10.3971/j.issn.1000-8578.2472

肺鳞癌中p53 与PCNA 的表达及临床意义

The Expression and Clinical Significance of p53 and Prol iferating Cell Nuclear Antigen (PCNA) in Lung Squamous Cell Carcinoma

摘要

摘要: 目的研究p53蛋白、增殖细胞核抗原(prolifeirating cell nuclear antigen PCNA)在肺鳞癌中的表达及其与临床病理的关系。方法采用免疫组化技术(S-P法)对36例肺鳞癌组织及10例正常支气管黏膜组织进行p53蛋白与PCNA的检测。结果 p53蛋白与PCNA在肺鳞癌组织中的表达明显高于正常组织，在肺鳞癌组织中的阳性表达率分别为58．3％(21／36)，91．7％(33／36)；PCNA强阳性表达率为61．1％(22／36)；p53阳性表达率及PCNA强阳性表达率均与肺癌组织的分化程度、肿瘤组织大小、淋巴转移等因素密切相关，差异具有显著性(P<0．05)；p53蛋白阳性表达与PCNA阳性表达呈正相关(P<0．05)。结论联合检测p53蛋白和PCNA对判断肺鳞癌的恶性程度、淋巴转移趋势具有重要价值。

Abstract: Objective 　To study the relationship between the expression of p53 and prolifera-ting cell nuclear antigen ( PCNA) in lung squamous cell carcinoma and clinicpathological features. Methods 　The expression of p53 and PCNA were detected in 36 cases of lung squamous cell carcinoma and 10 cases of normal lung tissues by SP immunohisto-chemistry. Results 　The positive rates of p53 and PCNA was 58. 3% (21/36) and 91.7 %(33/36) respectively. The positive rates of p53 and PCNA were correlated with histological grades, dimensions and lymph node metastasis. The differences were significant ( P < 0. 05) . The positive rates between p53 and PCNA were associated ( P < 0. 05) . Conclusion 　The detection of p53 and PCNA is valuable for evaluating the malignancy degree and lymph node metastasis of lung squamous cell carcinoma.

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