Abstract: Objective 　The expression of Paxillin and survivin in esophageal carcinoma and to investigate the relationship between the expression of Paxillin, survivin and carcinogenesis and progression of esophageal carcinoma. Methods 　Paxillin and Survivin expression were detected in 24 normal esophageal mucosa, 94 primary tumor tissues and 83 lymph nodes with SP immunohistochemistal method. Results 　The positive expression rate of Paxillin had the relationship with invasive depth, clinical staging and metastasis of lymph node ( P < 0. 05) . survivin had the relationship with invasive depth ( P < 0. 05) . The expression of Paxillin, survivin in positive lymph node was much higher than that in negative lymph node respectively ( P < 0. 05) . There was a positive relationship between Paxillin and survivin expression in this study ( P < 0. 05) . Conclusion 　Paxillin and survivin are over expressed in esophageal carcinoma. They play important roles in carcinogenesis and progression of esophageal carcinoma and can be used as valuable biomakers to evaluate biological characteristics in esophageal squamous cell carcinoma.