Abstract: Objective 　To elevate the level of the diagnosis and treatment of pheochromocytoma perioperatively. Methods 　52 patients underwent 24 hours urinary CA and plasma MN and NMN to ascertain the quality of tumor pre-operatively. 28 patients underwent 3D DCE MRA or CTA anatomical imaging. For controlling blood pressure, all patients were administ rated orally selective α1 inhibitor (controlled release tablets) Doxazosin (Cardura) . 30 patients applied AHH and Int raoperative autologous blood transfusion to compensate blood volume. Results 　The positive rate of 24 hours urinary CA was 86. 5 % in diagnosing pheochromocytoma ;plasma MN and NMN were 98. 1 %. 3D DCE MRA or CTA anatomical imaging supplied the clear picture around the tumor and showed the main blood supply. Cardura was efficacious to episodic hypertension. 23 patients avoided allo-transfusion by A HH and Intraoperative autologous blood transfusion. Conclusion 　Plasma MN and NMN were better than 24 hours urinary CA for diagnosis of pheochromcytoma. Anatomical imaging of 3D DCE MRA or CTA could be helpful in choosing the surgical pathway safely. Cardura was efficacious to episodic hypertension with little adverse effects. For persistent hypertension, we should take several anti-hypertensive drugs to cont rol blood pressure. AHH and Int raoperative autologous blood transfusion could reduce the medical cost s and avoid the allo-transfusion with more complications.