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液基细胞学与HPV检测对宫颈癌筛查的对比[J]. 肿瘤防治研究, 2002, 29(04): 303-305. DOI: 10.3971/j.issn.1000-8578.2373
引用本文: 液基细胞学与HPV检测对宫颈癌筛查的对比[J]. 肿瘤防治研究, 2002, 29(04): 303-305. DOI: 10.3971/j.issn.1000-8578.2373
Lquid-based cytologic screening compared with HPV testing to detect cervical cancer[J]. Cancer Research on Prevention and Treatment, 2002, 29(04): 303-305. DOI: 10.3971/j.issn.1000-8578.2373
Citation: Lquid-based cytologic screening compared with HPV testing to detect cervical cancer[J]. Cancer Research on Prevention and Treatment, 2002, 29(04): 303-305. DOI: 10.3971/j.issn.1000-8578.2373

液基细胞学与HPV检测对宫颈癌筛查的对比

Lquid-based cytologic screening compared with HPV testing to detect cervical cancer

  • 摘要: 目的 评价液基细胞学 (ThinPrep)和肿瘤相关人乳头瘤病毒 (HPV)检测对宫颈癌的筛查能力。方法 随机选择 35~ 4 5岁妇女同时做ThinPrep, 自取材HPV检测, 液基标本HPV检测和阴道镜活检。以阴道镜活检诊断为标准, 比较 3种检查对宫颈鳞状上皮内高度病变 (HSIL, CIN2 / 3)和鳞状细胞癌 (SCC)筛查的准确性。结果  1997例受检者中阴道镜活检诊断HSIL(CIN2 / 3) 74例, SCC12例。ThinPrep与自取材和液基标本HPV检测的敏感性无显著差异 (P >0 .0 5 )而特异性显著高于后两者 (P <0 .0 1)。 3种检查有较好的一致性。结论 ThinPrep细胞学和HPV检测是筛查宫颈癌可选用的方法

     

    Abstract: Objective To evaluate the capacity of Thin Prep and HPV in testing of vaginal samples. Methods Women were instructed to collect a vaginal sample for HPV testing, then exfoliative cervical samples and subsequent colposcopic biopsies were taken on all subjects.Cervical samples were collected into a liquid buffer and utilized for both cytologic screening using ThinPrep and HPV testing of residual liquid-based cytologic samples. All the tests were performed in an independent and blinded fashion. Results HSIL(...

     

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