~(131)I-3H11防治胃癌肝转移瘤形成的实验研究

The preventive study of gastric cancer cells liver metastasis in nude mice with RIT

摘要: 目的　研究术后131I 3H11腹腔灌注预防裸鼠人胃癌细胞肝转移的疗效。方法　于BALB/C裸鼠脾脏注入胃癌细胞后, 分为 5组, 按不同时间分别于腹腔注射131I 3H119.2 5MBq +N .S .4 0ml/kg ;对照组给N .S .。结果　 (1)肝转移发生率, 第 1组为 75 .0 %, 其它 4组均为 10 0 % ;(2 )平均肝转移瘤结节数目, A、B、C和D组分别为 1.75± 1.6 4个、8.0 0± 2 .0 0个、13.0 0± 3.35个和 16 .0 0± 4 .36个, 对照组E组为 2 0 .6 3± 3.77个 ;(3) 5组裸鼠生存时间分别为 :5 6 .2 5± 3.19d、4 5 .13± 3.6 6d、36 .88± 6 .11d、34.13± 2 .93d和 2 9.6 3± 5 .15d。结论　术后腹腔内运用131I 3H11可有效地减少肝转移发生率, 减少肝转移瘤结节数目和延长裸鼠的生存时间

Abstract: Objective To observe the preventive effect on gastric cancer cells liver metastasis with 131 I-3H11 I.P. postoperatively in nude mice. Methods Gastric cancer cells were injected into the spleen of each of the 40 BALB/C nude mice. Then the mice were divided into 5 groups as follows: 131 I-3H11 9.25MBq +N.S.40ml/kg I.P. postoperation respectively for group A, B, C and D. Group E was control. Results (1)The incidences of occurrence of liver metastases in group A was 75%, others were 100%. (2)The...