~(32)磷-玻璃微球治疗裸鼠人肝癌移植瘤的超微结构观察和立体定量学研究
An ultrastructural and morphometric study on the effect of phosphorus-32 glass microspheres (~(32)P-GMS) on the human hepatocellular carcinoma in nude mice
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摘要: 目的 探讨32 P GMS对肝癌的治疗作用和超微结构影响。方法 建立裸鼠人肝癌移植瘤后用32 P GMS进行治疗, 取治疗后瘤组织进行电镜观察和立体定量学研究。结果 实验组瘤细胞大量坏死, 部分瘤细胞出现了高分化肝癌的形态特征。实验组线粒体和粗面内质网体密度、毛细胆管和微绒毛面密度高于对照组(P <0 .0 1、0 .0 5、0 .0 1)。结论 研究表明32 P GMS抗肝癌作用明显, 并具有较好的促分化功能Abstract: Objective To study anticancer effect and ultrastructural influnce of 32 P-GMS injected to the hepatocellular carcinoma in nude mice. Methods The ultrastructural changes of tumor was examined by electron microscope and stereology . Results In treated group, a lot of tumor cells (35%～70%) were killed.Ultrastructurally,severe nuclear damage was observed in the death cells. Besides, well differentiated and degenerative tumor cells were seen.The skin and muscle neighboring to the t...
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