Abstract: Objective 　To evaluate the effect s of PANP on male patient s with rectal cancer following sexual dysfunction and urinary dysfunction. Methods 　Ret rospectively, the urinary dysfunction, sexual dysfunc2 tion and local recurrence rate of respective 56 patient s in case and cont rol group were analyzed by case2 cont rol study. Results 　The urinary dysfunction rate were 25. 00 % and 60. 71 % in case and cont rol group, and was found significant difference ( P < 0. 01) . The erectile dysfunction rate were 26. 79 % and 75. 00 % in case and cont rol group and was found significant difference ( P < 0. 01) . 28. 57 % and 69. 64 % of ejaculatory disorder in the two groups and had significance ( P < 0. 01) . Local recurrence was 7. 14 % and 8. 93 %, no significant difference was found in local recurrence between case and cont rol group. Con2 clusion 　The radical operation with pelvic autonomic nerve preservation for rectal cancer could reduce sexual disorder rate, urinary disorder rate and better life quality without at the expense of local recur2 rence.