Abstract: Objective 　To investigate the curative and adverse effect s of pantoprazole combined with gran2 iset ron for alimentary toxicities caused by tumor chemotherapy. Methods 　One hundred and twenty2five cases involved in int ractable vomiting caused by tumor chemotherapy were divided into two group s at ran2 dom on the second chemotherapy cycle. Sixty2four patient s of pantoprazole group were t reated with pan2 toprazole + graniset ron + dexathasone, and sixty2one ones of cont rol group were t reated with graniset ron + dexathasone. Results 　Pantoprazole group was superior to cont rol group in the prevention of appetite loss, nausea and vomiting with significant difference ( P < 0. 05) . Side2effect s such as headache, stomach2 ache, constipation, acratia, blushing, insomnia were similar ( P > 0. 05) . Conclusion 　Pantoprazole com2 bined with graniset ron is a good choice in prevention of alimentary toxicities caused by tumor chemothera2 py and worth extending it s clinical application.