放化疗结合治疗直肠癌术后复发

Effecting Observation of Stereotactic Radiotherapy Combined with Chemotherapy for Postoperative Local Recurrent Rectal Cancer

摘要: 目的探讨立体定向放射治疗结合化疗治疗直肠癌术后复发的疗效。方法回顾性分析61例直肠癌术后复发患者行立体定向放射治疗(4~5Gy/次,4次/周,总剂量48~50Gy/10~12次,2~3周)结合化疗(5-Fu0.75g/m2,d1~5;顺铂40mg/m2,d1~3)的疗效,在第4周以后重复该化疗方案4~5周期,生存分析采用Kaplan-Meier法。结果患者1、2、3年肿瘤局部控制率分别为86.9%、67.2%、37.7%;1、2、3年生存率分别为80.3%、62.3%、39.2%,中位生存期24.6个月;1、2、3年无瘤生存率分别为79.7%,52.5%、31.1%。急性放射性反应包括放射性肠炎和膀胱炎;晚期放射性反应包括放射性肠炎,骶丛炎和输尿管炎。结论立体定向放射治疗结合化疗是治疗直肠癌术后复发的有效姑息治疗方法。

Abstract: Objective To evaluate the effects of stereotactic radiotherapy(SRT)combined with chemotherapy for rectal cancer of postoperative local recurrence. Methods Sixty-one rectal cancer patients of postoperative local recurrence were treated with SRT(4～5Gy daily fraction;48-50Gy/2-3weeks) combined with chemotherapy(5-Fu(0.75),Days 1-5 and Days 29-33;Cisplatin 40mg,Days 1-3 and Days 29-31).Acute and late radiation reactions and survival rates were observed.Kaplan-Meier method was used for survival analysis. Results T...