survivin 基因在乳腺癌组织中的表达及其与HER-2 、p53 的关系

The Expression of survivin and Its Relationship with The Expression of Mutant p53, HER-2 in Breast Carcinoma

摘要: 目的研究survivin基因在乳腺癌中的表达及其与HER-2、突变型p53的关系。方法应用免疫组化法检测62例乳腺癌组织中survivin、HER-2、p53的表达。结果 62例乳腺癌组织中survivin、p53阳性率分别为67．7％、35．5％；HER-2过度表达率37．1％。survivin表达水平与患者临床病理特征及p53表达均无相关性（P〉O．05），与HER-2过度表达相关（P=0．013）。结论 survivin表达水平与HER-2过度表达相关；HER2基因与survivin基因之间可能存在某种调控通路。

Abstract: Objective 　To investigate the expression of survivin in breast carcinoma and to explore it s relationship with the expression of mutant p53, HER-2. Methods 　We examined the expression of survivin, mutant p53, HER-2 in 62 cases of breast carcinoma by immunohistochemical me thod. Results 　The expression of survivin was 67. 7 % and was independent of patient's clinicpathological factors. Although survivin expression was independent of the expression of mutant p53, it was positively correlated with HER-2 over2expression ( P = 0. 013) . Conclusion 　The expression of survivin in breast carcinoma was independent of the expression of mutant p53, but dependent of the over-expression of HER-2. It suggested that there was some regulatory relationship between HER-2 gene and survivin gene.