Abstract: Objective To investigate 7 cases of lymphomatoid papulosis (LyP) in order to analyze their clinical manifestations and pathological features and improve the clinical early diagnosis of LyP. Methods Histopathological method was used to study the morphological characteristics of LyP.The immunohistochemical determination of LCA,CD20、CD45RO、CD30、CD68 and HTLV-1 antibody of the routine paraffin samples of 7 cases with LyP was carried out using SP or ABC method. Results All patients presented with <1cm diameter recurrent papular eruptions over lower trunk and extremities.The clinical course of these patients was a chronic,clinically benign skin disorder.Histopathologically,the lesion were composed of numerous small or large atypical lymphoid cells which display antigen markers of T lymphocytes (CD45RO+) infiltrating perivascularity and periappendage of dermis.Follow-up,two patients died within 10 years and 17 years. Conclusion LyP is a type of pereipheral T cell lesion which is potentially malignant (borderline lesion).