长春瑞滨联合顺铂治疗晚期非小细胞肺癌160例近期疗效

Vinorelbine Plus Cisplatin Combination Chemotherapy in Advanced Non-small-cell Lung Cancer

摘要: 目的　观察长春瑞滨 (NVB)和顺铂 (DDP)联合治疗晚期非小细胞肺癌 (NSCLC)的临床疗效及毒副作用。方法　 160例Ⅲb～Ⅳ期初次治疗的非小细胞肺癌, 用NVB联合DDP(NP方案 )治疗 :NVB2 5mg/m2, 静滴d1,8,DDP 80mg/m2 静滴d1。结果　有效率 (CR +PR) 55.6%, 中位缓解期 6.2个月。中位生存期 12 .2个月。主要毒副反应为骨髓抑制。结论　NP方案治疗晚期非小细胞肺癌疗效高, 副反应少, 病人可耐受, 值得临床作为一线治疗推广

Abstract: Objective To evaluate the efficacy and toxicity of vinorelbine(NVB) plus cisplatin(NP regimen) combination chemotherapy in advanced non small cell lung cancer(NSCLC). Methods A total of 160 patients with advanced non small cell lung cancer were treated by NP regimen: NVB 25 mg/m 2,d 1,8 ; cisplatin 80 mg/m 2,d 1. All of them had stage Ⅲ b～Ⅳ disease, They were primary treatment. Results The overall response rate (RR) was 55.6%, The median response time 6.2 months. The median survival tim...