CF加5-Fu持续滴注联合AM方案治疗中晚期原发性肝癌临床研究

Clinical study of the effect of calcium folinate,5-Fluorouracil bolus and continuous infusion combined with AM regimen in the treatment of advanced primary hepatocellular carcinoma

摘要: 目的　观察大剂量醛氢叶酸 (CF)加氟尿嘧啶 (5 Fu)静脉持续滴注联合AM (ADM、MMC)方案治疗中晚期原发性肝癌临床疗效及不良反应, 探索中晚期原发性肝癌较合理治疗方案。方法　本研究采用CF 2 0 0mg/m2 +5 Fu 3g/m2 持续滴注 4 8小时联合AM(ADM、MMC)方案治疗 35例中晚期原发性肝癌, 对疗效及不良反应进行评价。结果　 17例达部分缓解 (PR), 15例为稳定 (SD), 3例为进展 (PD), 有效率为 4 8.6 %。不良反应主要为恶心呕吐、外周静脉炎、脱发、白细胞下降、口腔溃疡、腹泻等。上述不良反应绝大多数为Ⅰ～Ⅱ度反应, 病人可耐受。结论　大剂量醛氢叶酸 (CF)加氟尿嘧啶 (5 Fu)静脉持续滴注联合AM方案治疗中晚期原发性肝癌疗效较好, 不良反应较轻, 值得在临床上推广应用。

Abstract: Objective To observe the therapeutic effect and toxicity of high-dose-folinic acid plus 5-fluorouracil bolus and continuous infusion combined with AM regimen(Adriamycin、Mitomycin C) in advanced primary hepatocellular carcinoma. Methods Thirty-five patients with advanced primary hepatocellular carcinoma were treated with high-dose-folinic acid plus 5-fluorouracil bolus and continuous infusion 48 hours combined with AM regimen. The effect of treatment, toxicity was observed. Results There were seventeen pa...