宫颈上皮内瘤样病变及鳞癌中p53与MDM2蛋白表达差异性研究

Study of the Expression of p53,MDM2 Protein in Cervical Intra-epithelial Neoplasm and Cervical Squamous-cell Carcinoma

摘要: 目的　探讨MDM2、p53蛋白在宫颈癌发生、发展中的作用。方法　用免疫组化SP法检测MDM2及p53蛋白在正常宫颈上皮、宫颈上皮内瘤样病变 (CIN)、宫颈鳞癌 (SCC)中的表达, 共 76例。结果　 1.随着宫颈病变加重, MDM2、p53表达率均渐增高, 二者在正常宫颈、CIN、SCC的表达率分别为 :MDM2的表达为 0、 13 64%、 4 4 12 %;p53的表达为 5 0 0 %、18 18%、 4 7 0 6%。MDM2、p53在浸润癌组较CIN及正常宫颈组明显增高。 2 .MDM2的表达与p53的聚积在统计学上未显示出有相关性。结论　MDM2、p53可能参与宫颈癌的发生、发展, 对宫颈癌的诊断和治疗具有一定意义。

Abstract: Objective To study the roles of MDM2 and p53 protein playing in the pathogenesis and development of cervical carcinoma. Methods The expression of MDM2 and p53 protein in normal cervical epithelium,cervical intra-epithelial neoplasm(CIN) and invasive cervical squamous-cell carcinoma(SCC) were detected with immunohistochemical SP methods in 76 cases. Results 1.The expression rates of MDM2 and p53 were gradually increased with cervical lessions progress.The positive rates of MDM2 and p53 in normal cervical epith...