Abstract: Objective 　To study the expression of STAT3 in human carcinoma of larynx specimens. Meth2 ods 　The expression of STAT3 in human laryngeal carcinoma specimens was investigated by immunohis2 tochemical staining ; the expression of STAT3 mRNA in human laryngeal squamous cell carcinoma speci2 mens was examined by using RT2PCR. Results 　Immunohistochemical staining analysis revealed that STAT3 was expressed in 23 of 30 human laryngeal carcinoma specimens but was expressed in 2 of 8 non2 malignant laryngeal tissue ( P < 0. 05) . The mRNA of STAT3 are positive in 21 of 30 human laryngeal carcinoma specimens but positive in 2 of 8 nonmalignant laryngeal specimens ( P < 0. 05) . Conclusion 　Compared with nonmalignant laryngeal tissues, the expression level of STAT3 in laryngeal carcinoma tis2 sues was significantly higher ( P < 0. 05) . It suggest s that the expression of STAT3 may be related to the risk and development of laryngeal carcinoma.