羟基喜树碱膀胱灌注预防膀胱癌术后复发

Intravesical Instillation of HCPT to Prevent Recurrence after Surgery for Bladder Cancer

摘要: 目的　评估膀胱灌注羟基喜树碱预防膀胱癌术后复发的疗效。方法　应用羟基喜树碱膀胱灌注预防膀胱癌术后复发并与MMC进行随机对照观察。结果　羟基喜树碱组治疗 2 3例, 随访 6～ 36个月, 复发 3例, 复发率为 13 0 %。而MMC组治疗 2 2例, 随访 7～ 36个月, 复发 4例, 复发率为 18 2 %。结论　提示HCPT的疗效与MMC相仿, 而副作用明显减少, 认为羟基喜树碱是目前预防膀胱癌术后复发较理想的药物之一。

Abstract: Objective To evalute the results of intravesical HCPT instillation to prevent recurrence after surgery for bladder cancer. Methods A randomized and placebo-controlled trial on intravesical HCPT instillation versus MMC therapy for recurrence prevention in post operative bladder cancer patients was carried out. Results Twnty-three patients were treated with HCPT with.23 followed for 6 to 36 months.Three patients developed recurrence,recurrent rate was 13.0%.Twenty-two.patients were treated with MMC with 22 foll...