血清Ⅳ型胶原及层粘连蛋白在结直肠癌病人中的含量变化及其意义

Changes of Serum Collagen Type Ⅳ and Lominin Levels and Their Significance in Patients with Colon-rectal Carcinoma

摘要: 目的　观察结直肠癌病人血清Ⅳ型胶原 (ColⅣ )及层粘连蛋白 (LN)的含量变化并探讨其意义。方法　选择结直肠癌病人 51例作观察组 (其中 4 1例行根治术 ), 32例非肿瘤手术病人作对照组, 采用放射免疫法测定ColⅣ和LN。结果　观察组ColⅣ和LN的含量明显高于对照组(P <0 0 1), 其中DukesB期及C期明显高于A期 (P <0 0 1), 根治术后ColⅣ及LN较术前下降 (P<0 0 5)。结论　ColⅣ及LN与结直肠癌的浸润转移相关, 检测其含量有助于判断病情和预后。

Abstract: Objective To observe the change of serum collagen type Ⅳ(ColⅣ)and lominin(LN)levels in patients with colon-rectal carcinoma and to study it's significance. Methods 51 cases with colon-rectal carcinoma were selected as Treating Group(among which 41 cases received radical operation).32 cases with non-tumor operation were taken as Control Group.ColⅣ and LN levels were determined with radioimmunoassay. Results ColⅣ and LN levels of Treating Group were markedly higher than those of Control Group(both P <0.01...