吉西他滨联合奥沙利铂和强的松治疗复发性或难治性非霍奇金淋巴瘤20例报告

doi:10.3971/j.issn.1000-8578.2035

吉西他滨联合奥沙利铂和强的松治疗复发性或难治性非霍奇金淋巴瘤20例报告

Effect of Gemcitabine Plus Oxaliplatin and Prednisone(GPP) in Treatment of Fwenty Patients with Relapsed or Refractory Non-hodgkin s Lymphoma

摘要

摘要: 目的观察低剂量吉西他滨24小时持续静脉滴注联合奥沙利铂、强的松（GPP方案）治疗复发性及难冶性非霍奇金淋巴瘤（NHL）的近期疗效。方法20例复发性及难治性NHL患者，应用GPP方案，即：Gem 120mg／m^2，24小时持续静脉滴注，d1.8，L—OHP 80mg／m^2，静脉滴注，d1.8；PDN60mg／m^2，口服，d1～5；21d为1周期，完成2周期以上者做疗效评价。结果20例患者中，CR6例，PR8例，NC3例，PD3例，总有效率（CR＋PR）为70％。结论GPP方案治疗复发性及难治性NHL的近期疗效满意，毒性反应可耐受。

Abstract: Objective 　To evaluate the short2term efficacy of low2dose Gemcitabine 24 h continuous infu2 sion plus Oxaliplatin and Prednisone ( GPP) regimen in the t reatment with relapsed or ref ractory non2 Hodgkin's lymphoma (N HL) . Methods 　Twenty cases with relapsed or ref ractory N HL were t reated with GPP regimen : Gem 120 mg/ m2, 24 h continuous infusion, d1, 8 ;L2OHP 80 mg/ m2, ivgtt, d1, 8 ; PDN 60 mg/m2, p . o, d1～5 ; Every 21 days is one cycle. Their clinical response was assessed af ter 2 cycles of chemo2 therapy. Results 　In the 20 cases, the complete response was 6 cases, the partial response was 8 cases, 3 cases was no change, 3 case was progressive, the overall response rate (CR + PR) was 70 %. Conclusion 　GPP regimen can achieve a satisfied result in the t reatment of relapsed or ref ractory N HL, and the toxici2 ty was endurable.

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