血液学指标在儿童及青少年鼻咽癌中的预后价值

袁芳琴; 王藤; 郭文杰; 何侠; 尹丽

doi:10.3971/j.issn.1000-8578.2023.22.1446

血液学指标在儿童及青少年鼻咽癌中的预后价值

Prognostic Value of Hematological Indicators in Children and Adolescents with Nasopharyngeal Carcinoma

摘要

摘要:
目的探讨治疗前血液学指标在儿童及青少年鼻咽癌中的预后价值。
方法回顾性分析79例儿童及青少年（≤20岁）鼻咽癌患者的病历资料。治疗前所有患者均进行血液学检查，患者接受单纯调强放疗或调强放疗联合化疗、靶向等综合治疗模式。随访终点为总生存（OS）及无进展生存（PFS）。
结果单因素分析结果显示年龄≤14岁、无同步化疗、治疗前血液学指标（高NLR、高PLR、高LDH、高LAR）与儿童及青少年鼻咽癌较差的OS、PFS有关（均P < 0.05），无同步化疗、治疗前高LAR（P=0.019）是儿童及青少年鼻咽癌患者OS的独立不良预后因素（均P < 0.05）。
结论治疗前血液学指标中高NLR、PLR、LDH、LAR与较差的OS、PFS相关，其中，治疗前高LAR是儿童及青少年鼻咽癌患者OS的独立不良预后因素。

Abstract:
Objective To explore the prognostic value of pretreatment hematological indicators in children and adolescents with nasopharyngeal carcinoma.
Methods We performed a retrospective analysis on the medical records of 79 children and adolescents (≤20 years old) with nasopharyngeal carcinoma. Before treatment, all patients underwent hematological tests, and patients received intensity-modulated radiotherapy alone or intensity-modulated radiotherapy combined with chemotherapy, targeted, and other comprehensive treatment modes. The follow-up endpoints were overall survival (OS) and progression-free survival (PFS).
Results Age≤14 years, no concurrent chemotherapy, pretreatment hematological indicators (high NLR, high PLR, high LDH, and high LAR) were associated with poor OS and PFS in children and adolescents with nasopharyngeal carcinoma (all P < 0.05). No concurrent chemotherapy and high LAR before treatment were independent adverse prognostic factors for OS in children and adolescents with nasopharyngeal carcinoma.
Conclusion High NLR, high PLR, high LDH, and high LAR of pretreatment hematological indicators are associated with poor OS and PFS. Meanwhile, high LAR before treatment is an independent adverse prognostic factor for OS in children and adolescents with nasopharyngeal carcinoma.

HTML全文

参考文献(31)

施引文献

资源附件(0)