鼻咽癌细胞葡萄糖代谢的分子机制及其与侵袭转移关系的研究进展

Research Progress on Correlation of Glucose Metabolism Mechanism with Invasion and Metastasis of Nasopharyngeal Carcinoma Cells

摘要: 转移是造成癌症死亡的主要原因。越来越多的证据表明，鼻咽癌细胞葡萄糖代谢的改变可以通过多种途径影响其侵袭转移的发生。本文总结了鼻咽癌细胞葡萄糖代谢异常的分子机制并对其与鼻咽癌侵袭转移的关系进行分析，包括有氧糖酵解、有氧氧化、磷酸戊糖途径等与鼻咽癌侵袭转移的关系，旨在从葡萄糖代谢途径靶向治疗鼻咽癌侵袭转移提供新思路与新途径。

Abstract: Metastasis is the main cause of cancer-related death. Growing evidence has shown that changes in glucose metabolism in nasopharyngeal carcinoma cells affect the invasion and metastasis of nasopharyngeal carcinoma through many pathways. This review summarizes the molecular mechanism underlying abnormal glucose metabolism in nasopharyngeal carcinoma cells and analyzes its relationship with the invasion and metastasis of nasopharyngeal carcinoma, including aerobic glycolysis, aerobic oxidation, and pentose phosphate pathway. The aim is to provide novel approaches using the relationships among glucose metabolism, invasion, and metastasis in the targeted therapy of nasopharyngeal carcinoma.