Abstract: Cervical cancer is one of the most common malignant tumors in women. The incidence rate fourth in all female malignant tumors. The occurrence of cervical cancer is closely related to high-risk HPV infection. Cervical squamous intraepithelial lesion is a pathological change caused by HPV infection, and may progress to cervical precancerous lesions or even cancer. Therefore, accurate screening of cervical intraepithelial lesions and individualized diagnosis and treatment plan are of great significance to prevent the occurrence and development of cervical cancer. This article reviews the progress on the diagnosis and treatment of cervical high-grade squamous intraepithelial lesions.