Abstract: Hepatocellular carcinoma (HCC) has high mortality, low early diagnosis rate, relatively poor treatment outcomes and prognosis. ¹⁸F-FDG PET/CT has an important application value on the detection of HCC metastasis, early recurrence and treatment prognosis. This paper summarizes and reviews the research progress on the application of ¹⁸F-FDG PET/CT in HCC diagnosis, liver transplantation, surgical resection and local ablation, to provide references for clinicians to make rational use of ¹⁸F-FDG PET/CT imaging technology in accurate diagnosis and treatment of HCC.