PTBP1与肿瘤发展和治疗关系的研究进展
Research Progress on Relation Between BTBP1 and Tumor Progression and Treatment
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摘要: 多聚嘧啶区结合蛋白1（PTBP1，也被称为hnRNP I）是一种研究广泛的RNA结合蛋白，参与调控mRNA剪接、翻译、稳定性和定位。PTBP1可参与多种非编码RNA的作用过程，影响肿瘤的发生与发展。在肿瘤治疗方面，PTBP1可能作为关键因子影响靶向药物作用靶点以及肿瘤耐药性。本文就PTBP1在肿瘤中的作用及其在肿瘤治疗中的研究进展作一综述。Abstract: PTBP1, a widely-studied RNA binding protein, regulates mRNA splicing, translation, stability and localization. PTBP1 participates in a variety of ncRNA acting processes, affects tumorigenesis and tumor progression. In terms of tumor therapy, PTBP1 may act as a key factor to affect the target of targeted drugs and influence tumor resistance. This article reviews the role of PTBP1 in tumor and its research progress in tumor treatment.
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