代谢综合征及低水平高密度脂蛋白胆固醇与前列腺癌根治术后不良病理特征的相关性

韩俊岭; 陈昆; 翟晓磊; 韩前河; 单中杰

doi:10.3971/j.issn.1000-8578.2022.21.1112

代谢综合征及低水平高密度脂蛋白胆固醇与前列腺癌根治术后不良病理特征的相关性

Correlation of Metabolic Syndrome and Low-level High-density Lipoprotein Cholesterol with Adverse Pathological Features of Prostate Cancer After Radical Prostatectomy

摘要

摘要:
目的探究代谢综合征(MetS)及低水平高密度脂蛋白胆固醇(HDL-C)与根治性前列腺切除术(RP)后前列腺癌(PCa)侵袭性的相关性。
方法收集232例接受RP的PCa患者的各项生理指标并进行前瞻性多中心研究。将伴有MetS的患者设为MetS组(MetS), 无MetS的患者设为非MetS组(No MetS)。MetS按照NCEP-ATP Ⅲ进行评估。局部晚期PCa为pT-分期≥3;采用Gleason评分系统进行病理分级; MetS及其各项指征与病理特征的相关性采用回归分析进行评估。
结果 MetS是RP术后Gleason评分≥8的独立风险因素。低水平HDL-C与局部晚期PCa相关。随着患者出现MetS指征数目增多, 出现不良病理特征的风险增加。
结论低水平HDL-C和具备4个及以上MetS指征分别与更高风险的PCa不良病理特征相关。

Abstract:
Objective To assess the association of metabolic syndrome (MetS) and low-level high density lipoprotein-cholesterol (HDL-C) with the invasion of prostate cancer (PCa) in the patients after radical prostatectomy (RP).
Methods We collected and analyzed the data of 232 PCa patients treated with RP for prospective multicenter clinical study.The MetS was assessed according to NCEP-ATP Ⅲ.Patients were divided into MetS group and non-MetS group.Locally advanced PCa was defined as a pT-stage≥3.ISUP Gleason grading system (GS) were used for pathological grading.Logistic regression analyses assessed the association of MetS and its components with pathological data.
Results MetS was an independent risk factor for GS≥8 after RP.Low HDL-C level was associated with locally advanced PCa.The risks of adverse pathological features increased with the number of MetS components.
Conclusion Low HDL-C level and 4 or more MetS components are associated with higher risk of adverse pathological features of PCa.

HTML全文

参考文献(18)

施引文献

资源附件(0)