艾滋病合并恶性肿瘤患者临床特点及预后影响因素

雷海科; 李小升; 李杰平; 刘俊; 肖春燕; 王颖; 张维; 刘耀; 吴永忠

doi:10.3971/j.issn.1000-8578.2022.21.1056

艾滋病合并恶性肿瘤患者临床特点及预后影响因素

Clinical Characteristics and Prognostic Influence Factors of Patients with AIDS-related Malignant Tumor

摘要

摘要:
目的分析艾滋病病毒（HIV）感染者/艾滋病（AIDS）合并恶性肿瘤患者的临床特点及生存预后情况。
方法回顾性分析354例艾滋病合并恶性肿瘤患者资料，采用Log-rank检验进行单因素分析，采用Cox比例风险回归模型进行多因素分析。
结果患者平均年龄54.10±12.96岁，男女比例2.1:1，艾滋病合并淋巴瘤的患者最多（28.25%）；1、3、5年生存率分别为78.48%、62.13%、55.31%。单因素分析显示不同恶性肿瘤类型、年龄、性别、医保类型、确诊合并艾滋病后住院次数、平均住院天数、是否放疗、有无遵医嘱离院等患者的预后差异均有统计学意义；多因素分析显示性别、入院次数、平均住院天数、自费比例以及有无遵医嘱离院是影响患者生存预后的独立危险因素。
结论艾滋病容易合并淋巴瘤、肺癌、宫颈癌。患者在医院接受抗肿瘤疗程不足。

Abstract:
Objective To analyze the clinical characteristics and survival prognosis of patients with AIDS-related malignant tumor.
Methods We retrospectively analyzed the data of 354 patients with AIDS-related malignant tumor. Univariate analysis was conducted by Log rank test and multivariate analysis was conducted by Cox proportional risk regression model.
Results The average age of the patients was 54.10±12.96 years old. The ratio of male to female patients was 2.1:1. The number of patients with AIDS complicated with lymphoma was the most, accounting for 28.25%. The 1-, 3- and 5-year survival rates were 78.48%, 62.13% and 55.31%, respectively. Univariate analysis showed that there were statistical differences in prognosis of patients with different types of malignant tumor, age, gender, medical insurance type, number of admissions after diagnosis of AIDS, average length of stay, radiotherapy or not, leaving hospital according to medical advice. Multivariate analysis showed that gender, number of admissions after diagnosis of AIDS, average length of stay, proportion of out-of-pocket and leaving hospital according to medical advice were independent risk factors affecting the survival and prognosis of patients.
Conclusion AIDS is easily complicated with lymphoma, lung cancer and cervical cancer. The patients received insufficient anti-tumor courses in hospital.

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