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唐银炳, 张鹤腾, 张文波, 蒋鹏程. 长链非编码RNA作为ceRNA在胃癌上皮间质转化中的作用研究进展[J]. 肿瘤防治研究, 2022, 49(4): 352-358. DOI: 10.3971/j.issn.1000-8578.2022.21.0863
引用本文: 唐银炳, 张鹤腾, 张文波, 蒋鹏程. 长链非编码RNA作为ceRNA在胃癌上皮间质转化中的作用研究进展[J]. 肿瘤防治研究, 2022, 49(4): 352-358. DOI: 10.3971/j.issn.1000-8578.2022.21.0863
TANG Yinbing, ZHANG Heteng, ZHANG Wenbo, JIANG Pengcheng. Research Progress on Roles of lncRNA as ceRNA in EMT of Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2022, 49(4): 352-358. DOI: 10.3971/j.issn.1000-8578.2022.21.0863
Citation: TANG Yinbing, ZHANG Heteng, ZHANG Wenbo, JIANG Pengcheng. Research Progress on Roles of lncRNA as ceRNA in EMT of Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2022, 49(4): 352-358. DOI: 10.3971/j.issn.1000-8578.2022.21.0863

长链非编码RNA作为ceRNA在胃癌上皮间质转化中的作用研究进展

Research Progress on Roles of lncRNA as ceRNA in EMT of Gastric Cancer

  • 摘要: 胃癌是世界上最常见的恶性肿瘤之一。上皮间质转化(EMT)在胃癌的进展和转移中发挥着关键作用。EMT的调控是一个复杂的网络,转录因子SNAIL/SLUG、TWIST1/2、ZEB1/2在肿瘤EMT的过程中发挥着重要诱导作用,此外EMT的调控还与细胞因子、miRNAs(如miR-200家族)等的参与有关。近些年随着非编码RNA研究的深入,ceRNA网络被发现,其涉及lncRNA、circRNA、miRNA和mRNA等多个RNA分子,可广泛调控肿瘤细胞的增殖和转移,与EMT的关系密切。本文综述了lncRNA 作为ceRNA在胃癌EMT中发挥的作用和分子机制,从而加深对胃癌等恶性肿瘤中ceRNA网络的认识。

     

    Abstract: Gastric cancer is one of the most common malignant tumors in the world, and EMT plays a key role in the development and metastasis of gastric cancer. The regulation of EMT is a complex network. Transcription factors such as SNAIL/SLUG, Twist1/2 and ZEB1/2 play an important induction role in the process of tumor EMT. In addition, the regulation of EMT is related to the participation of cytokines and miRNAs (such as miR-200 family). In recent years, with the deepening studies on non-coding RNAs, researchers discovered that ceRNA networks, involving lncRNA, circRNA, miRNA, mRNA and other RNA molecules, can extensively regulate the proliferation and metastasis of tumor cells, and are closely related to EMT. This paper reviews the role and molecular mechanism of lncRNA as ceRNA in EMT of gastric cancer, to deepen the understanding of ceRNA network in gastric cancer and other malignant tumors.

     

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