LncRNA NKILA对肿瘤恶性生物学行为的影响及机制

Influence of LncRNA NKILA on Biological Behavior of Malignant Tumors and Related Mechanism

摘要: NKILA（NF-kappaB interacting lncRNA）是一种新近发现的长链非编码RNA，其在诸多恶性肿瘤中呈现异常表达。现有研究已证实NKILA主要通过NF-κB信号通路参与调控肿瘤的发生和发展，对肿瘤的诊断、治疗和患者预后的评估都有重要意义。本文将对NKILA在多种肿瘤中的异常表达情况和生物学功能作一综述，并对不同肿瘤中NKILA调控恶性生物学行为的上下游机制进行总结与归纳。

Abstract: NKILA is a kind of newly-discovered lncRNA whose expression is aberrant in diverse malignant tumors. The existing researches have confirmed that NKILA participates in the occurrence and development of tumors mainly by regulating the NF-κB signaling pathway, and has significance to the cancer diagnosis, treatment and prognostic evaluation of patients. This article reviews the abnormal expressions and biological effects of NKILA, and the up- and down-stream mechanisms of NKILA regulating malignant biological behavior in different cancers.