CD47与淋巴瘤免疫治疗相关性的研究进展

Research Progress on Relation Between CD47 and Immunotherapy on Lymphoma

摘要: CD47属于免疫球蛋白超家族成员，在人体多种细胞和组织上均有表达，但在肿瘤细胞上表达得更多，特别是在各种造血系统肿瘤中高表达。肿瘤细胞上表达的CD47与巨噬细胞上的信号调节蛋白α（SIRPα）结合抑制巨噬细胞对肿瘤的吞噬作用可导致肿瘤免疫逃逸。近年来CD47成为肿瘤研究的新热点，本文就CD47的结构与表达、CD47-SIRPα、靶向CD47抗体药物与淋巴瘤免疫治疗相关性研究作一综述。

Abstract: CD47 is a member of the immunoglobulin superfamily. It is expressed on various cells and tissues of human, but it is more expressed on tumor cells, especially in various hematopoietic tumors. The combination of CD47 expressed on tumor cells with signal regulator protein α (SIRPα) on macrophages inhibits the phagocytosis of tumors by macrophages. The reaction can lead to tumor immune escape. CD47 has become a new hot spot in tumor research. This article reviews the correlation between the structure and expression of CD47, CD47-SIRPα, CD47-targeting antibody drugs and lymphoma immunotherapy.