代谢综合征与胃癌发病风险的Meta分析

梁桐; 刘华杰; 达明绪

doi:10.3971/j.issn.1000-8578.2021.20.0957

代谢综合征与胃癌发病风险的Meta分析

Metabolic Syndrome and Risk of Gastric Cancer: A Meta-analysis

摘要

摘要:
目的采用Meta法评价代谢综合征（MetS）与胃癌（GC）发病风险的关系。
方法计算机检索CNKI、WanFang Data、VIP、CBM、Web of Science、The Cochrane Library及PubMed数据库，搜集国内外关于MetS与GC相关的病例—对照研究，检索时限均为建库至2020年6月。由两位研究者独立筛选文献、提取资料及评价纳入文献的质量，采用Stata 12.0软件对纳入文献进行Meta分析。
结果最终纳入6篇文献，共计43 617例研究对象。Meta分析结果显示，GC与非GC人群发生高血糖、高血压及MetS的风险比较，两者差异均无统计学意义（高血糖：OR=1.24, 95%CI: 0.59~2.61; 高血压：OR=1.40, 95%CI: 0.60~3.25; MetS: OR=0.79, 95%CI: 0.44~1.39）。
结论 MetS可能与GC发病风险不相关。

Abstract:
Objective To evaluate the relation between metabolic syndrome (MetS) and gastric cancer (GC) based on a meta-analysis.
Methods The case-control studies about the relation between MetS and GC were retrieved from CNKI, WanFang Data, VIP, CBM, Web of Science, The Cochrane Library and PubMed database. The retrieval time was from inception to June, 2020. Two researchers independently screened the literatures, extracted the data and evaluated the quality of the included studies. The meta-analysis of the included literatures was conducted by the Stata 12.0 software.
Results A total of six literatures, involving 43617 participants, were included. The results of meta-analysis showed that there was no statistically significant difference between GC and non-GC groups in the risk of hyperglycemia (OR=1.24, 95%CI: 0.59-2.61), hypertension (OR=1.40, 95%CI: 0.60-3.25) or MetS (OR=0.79, 95%CI: 0.44-1.39), respectively.
Conclusion MetS may not be related to the risk of GC.

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