恶性肿瘤家族史与乳腺癌患者临床病理特征的关系

曹欣华; 韩丽飞; 吕建鑫; 胡浩霖; 张亚男

doi:10.3971/j.issn.1000-8578.2020.20.0027

恶性肿瘤家族史与乳腺癌患者临床病理特征的关系

Association Between Family History of Malignant Neoplasms and Clinicopathological Features of Breast Cancer Patients

摘要

摘要:
目的探讨恶性肿瘤家族史(MN-FH)与乳腺癌患者临床病理特征之间的关系。
方法回顾性分析东南大学附属中大医院2016年1月—2018年12月收治的417例乳腺癌患者的临床病理资料，根据有无MN-FH分成两组。采用χ²检验分析两组患者临床病理特征之间的关系。
结果 417例乳腺癌患者中，有MN-FH者67例(16.1%)。有MN-FH组的患者有更高比例的脉管癌栓(P=0.046)和淋巴结转移(P=0.023)，肿瘤更易表现为ER阴性(P=0.025)、PR阴性(P=0.031)和HER2阳性(P=0.041)。进一步亚组分析发现，有乳腺癌家族史的患者较无MN-FH的患者有更晚的肿瘤分期(P=0.011)，肿瘤更易表现为三阴性和HER2扩增型(P=0.010)。其他恶性肿瘤家族史的患者较无MN-FH的患者有更高比例的脉管癌栓(P=0.036)和淋巴结转移(P=0.034)。
结论有MN-FH的乳腺癌患者肿瘤恶性程度更高，对于有MN-FH的人群体检非常重要。

Abstract:
Objective To investigate the association between family history of malignant neoplasms (MN-FH) and clinicopathological characteristics of patients with breast cancer.
Methods We analyzed retrospectively the clinical data of 417 breast cancer patients in Zhong Da Hospital from January 2016 to December 2018. Patients were grouped based on MN-FH or non-MN-FH. The clinical and pathological features of the patients were analyzed by χ² test.
Results Among 417 breast cancer patients, 67(16.1%) cases had MN-FH. Compared with non-MN-FH group, MN-FH group had higher proportion of vascular thrombosis (P=0.046), lymph node metastasis (P=0.023), ER negative (P=0.025), PR negative (P=0.031) and HER2 positive (P=0.041). In the further subgroup analysis, compared with non-MN-FH patients, patients with breast cancer history had higher tumor stage (P=0.011) and the tumors were more likely to be triple-negative and HER2-positive (P=0.010). Breast cancer patients with family history of other malignant tumors had higher proportion of vascular thrombosis (P=0.036) and lymph node metastasis (P=0.034).
Conclusion Breast cancer patients with MN-FH have higher degree than non-MN-FH patients. For people with MN-FH, physical examination is very important.

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